Novel genomic variants related to visceral adiposity index (VAI) and body adiposity index (BAI) in Indian sib-pairs
Authors' conclusion
We report three novel genetic loci for VAI, and BAI in Indians that are important indicators of adiposity. These findings need to be replicated and validated with larger samples from different ethnicities. Further, functional studies for understanding the biological mechanisms of these adiposity indices need to be undertaken to understand the underlying pathophysiology.
Study context
- Population
- Sib-pairs from the Indian Migration Study; variants from the Cardio-Metabochip array2,265 sib-pairs
- Outcome
- Association of genetic variants with VAI and BAI
Methodological detailssib-pair design, within-sib component of Fulker's association models, mixed linear regression
- Sib-pair design
- Within-sib component of Fulker's association models
- Mixed linear regression
Main finding
As reported in the abstract
rs6659428 at LOC400796 | SEC16B with VAI
β = 0.26, SE = 0.05
rs7611535 at DRD3 | LOC645180 with VAI
β = 0.18, SE = 0.04
rs73300702 at JAZF1-AS1 with BAI (top hit, p value < 8.21 × 10-6)
β = 0.27, SE = 0.06
Further findings
Gene-environment/lifestyle interaction
- rs6659428: marginal effect modification with rural/urban location
- β = 0.26, SE = 0.13, p value = 0.047
- rs73300702: marginal effect modification with physical activity
- β = −0.29,SE = 0.14, p value = 0.034
Original publication
Novel genomic variants related to visceral adiposity index (VAI) and body adiposity index (BAI) in Indian sib-pairs. Int J Obes (Lond). Published 7 July 2024. doi:10.
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