Different effects of bariatric surgery on epigenetic plasticity in skeletal muscle of individuals with and without type 2 diabetes
Authors' conclusion
OB and T2D exhibit differential skeletal muscle transcriptome responses to bariatric surgery, presumably resulting from perturbed epigenetic flexibility.
Study context
- Population
- Individuals with obesity with and without T2D undergoing bariatric surgery
- Participants
- 13 vs 13
- Comparison
- Bariatric surgery effects in individuals with T2D vs without
- OBn = 13reference
- T2Dn = 13
- Outcome
- Skeletal muscle transcriptome and methylome response to surgery-induced weight loss
- Follow-up
- One year after surgery
Methodological detailsbefore-after (before and one year after surgery), skeletal muscle biopsies, transcriptome and methylome analyses
- Before-after (before and one year after surgery)
- Skeletal muscle biopsies
- Transcriptome and methylome analyses
Main finding
As reported in the abstract
one year after surgery
Differentially expressed genes, OB
2,013
Differentially expressed genes, T2D
959
Further findings
Metabolic phenotype · before and after surgery
- Before surgery, T2D had higher fasting glucose and insulin but lower whole-body insulin sensitivity than OB
- After surgery, only glycemia remained higher in T2D than OB
Original publication
Different effects of bariatric surgery on epigenetic plasticity in skeletal muscle of individuals with and without type 2 diabetes. Diabetes Metab. Published 6 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →