Novel markers and networks related to restored skeletal muscle transcriptome after bariatric surgery
Authors' conclusion
Previously unknown gene networks and marker genes underlined the important role of FFA in restoring muscle gene expression after bariatric surgery and further suggest novel therapeutic targets for obesity.
Study context
- Population
- Lean people and people with obesity undergoing bariatric surgery; discovery and replication cohorts
- Comparison
- Skeletal muscle transcriptome of people with obesity before and 1 year after bariatric surgery vs lean people
- Outcome
- Skeletal muscle gene expression restored after bariatric surgery
- Follow-up
- 1 year after surgery
Methodological detailsweighted gene co-expression network analysis (WGCNA), least absolute shrinkage and selection operator (LASSO) regression, replication cohort
- Weighted gene co-expression network analysis (WGCNA)
- LASSO regression
- Replication cohort
Main finding
As reported in the abstract
- Genes differing between individuals with and without obesity no longer different 1 year after surgery (restoration)
- 440 genes
- Genes with normalized expression clustered by WGCNA in one major module, correlating particularly to weight loss and decreased plasma free fatty acids (FFA)
- 116 genes
- Module genes showing an obesity-related phenotype upon deletion in mice
- 44
- Module genes that were prominent markers for reduced FFA concentration
- 105
- Marker genes for decreased BMI in both discovery and replication cohorts
- 55
Original publication
Novel markers and networks related to restored skeletal muscle transcriptome after bariatric surgery. Obesity (Silver Spring). Published 12 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →