Association of Body Weight Time in Target Range With the Risk of Kidney Outcomes in Patients With Overweight/Obesity and Type 2 Diabetes Mellitus
Authors' conclusion
A higher body weight TTR, with a weight loss target of losing ≥7% of initial weight, was associated with a lower risk of kidney outcomes in participants with overweight/obesity and T2DM.
Study context
- Population
- Participants with overweight/obesity and T2D with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m², Look AHEAD trial435 composite kidney outcome cases
- Participants
- 3,601 participants
- Comparison
- Body weight time in target range (TTR) categories during first 4 years
- Primary endpoint
- Composite kidney outcome:
- eGFR decline ≥30% from baseline and to <60 mL/min/1.73 m² at follow-up visit
- End-stage kidney disease
- Follow-up
- Median 8.0 years
Primary result
As reported in the abstract
Composite kidney outcome
Adjusted hazard ratio (95% CI)
Per SD increment in body weight TTRinverse association
0.81(0.70–0.93)
TTR >0% to <29.9%vs TTR 0%
0.73(0.54–1.00)
TTR 29.9% to <69.7%vs TTR 0%
0.71(0.52–0.99)
TTR 69.7% to <100%vs TTR 0%
0.54(0.36–0.80)
Secondary outcomes
- Similar results found for doubling of urine albumin to creatinine ratio
Original publication
Association of Body Weight Time in Target Range With the Risk of Kidney Outcomes in Patients With Overweight/Obesity and Type 2 Diabetes Mellitus. Diabetes Care. Published 11 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →