Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus
Authors' conclusion
In this post hoc analysis of the Look AHEAD trial, longitudinal declines in FM and WC were associated with a lower risk of kidney outcomes in the ILI group in participants with overweight/obesity and T2DM.
Study context
- Population
- Participants with overweight/obesity and T2D with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m², Look AHEAD trial
- Participants
- 3,927 participants
- Comparison
- Longitudinal changes in fat mass (FM), lean mass (LM) and waist circumference (WC) and kidney outcomes, by trial arm
- Primary endpoint
- Kidney outcomes: eGFR decrease of at least 40% from baseline at follow-up visit, or end-stage kidney disease
- Follow-up
- Median 8.0 years
Methodological detailspost hoc analysis
- Post hoc analysis
Primary result
As reported in the abstract
Kidney outcomes by 1-year change in body composition, ILI · baseline to 1-year follow-up
FM reduction (per 10% decrease), aHR
0.80 (0.69-0.94) (95% CI)
WC reduction (per 10% decrease), aHR
0.72 (0.59-0.88) (95% CI)
LM change (per 10% decrease), aHR (95% CI), not significant
0.78
0.58–1.06
Kidney outcomes documented after the first 1 year
450
Further findings
Kidney outcomes by 4-year change in body composition
- Similar results to the 1-year changes
Original publication
Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus. Diabetes Obes Metab. Published 10 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →