Patterns of weight change during adulthood and incidence of nephrolithiasis: a population-based study
Authors' conclusion
This study found that changes in weight during adulthood are linked to the risk of developing kidney stones. Maintaining healthy weight during adulthood is important for reducing the risk of developing kidney stones.
Study context
- Population
- Participants aged 30–75 years with body mass index (BMI) recorded at baseline and 10 years prior to the survey
- Participants
- 14,472 participants
- Exposure
- Adult weight change patterns vs stable healthy weight
- Outcome
- Incident kidney stone
Methodological detailslogistic regression adjusted for covariates, restricted cubic spline regression, population attributable fraction
- Logistic regression adjusted for covariates
- Restricted cubic spline regression
- Population attributable fraction
Main finding
As reported in the abstract
Kidney stone
Each group vs stable healthyOdds ratio (95% CI)
Non-obesity to obesity
1.59(1.18–2.13)
Obesity to non-obesity
1.78(1.47–2.16)
Stable obesity
1.80(1.48–2.19)
Observational data: associations, not effects.
Further findings
Absolute weight change and kidney stone (restricted cubic spline (RCS))
- U-shaped association; risk lowest with stable healthy BMI
Population attributable fraction (PAF) of maintaining healthy BMI
- Lower incidence of kidney stones if population had maintained healthy BMI
- 28.7% (95% CI: 18.6%-37.5%)
Original publication
Patterns of weight change during adulthood and incidence of nephrolithiasis: a population-based study. Int J Obes (Lond). Published 9 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →