Isthmin-1 (ISM1), a novel adipokine that reflects abdominal adipose tissue distribution in individuals with obesity
Authors' conclusion
The study's results support the hypothesis that the SC-VIS fat ratio and its derived non-invasive biomarkers can comprehensively assess obesity-related health risks. ISM1 could predict abdominal fat partitioning and be a potential biomarker for evaluating obesity-related health risks.
Study context
- Population
- Individuals with obesity; abdominal fat distribution measured by CT
- Participants
- 125 individuals
Main finding
As reported in the abstract
- Significant differences in abdominal fat distribution (CT) among genders and obesity models (visceral, subcutaneous, subcutaneous (SC)/visceral (VIS) ratio)
- SC/VIS ratio emerged as an excellent metric to differentiate metabolic status
- ISM1 levels in SC fat correlated with plasma ISM1
- Serum adipokine levels correlated with SC/VIS ratio
- ROC analysis: ISM1 discriminated individuals with favorable metabolic profiles based on adipose tissue distribution
- Correlation analysis suggested ISM1 involvement in glucose regulation pathways
Original publication
Isthmin-1 (ISM1), a novel adipokine that reflects abdominal adipose tissue distribution in individuals with obesity. Cardiovasc Diabetol. Published 8 December 2023. doi:10.
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