Normative cut-offs for polycystic ovary syndrome diagnostic features in adolescents using cluster analysis
Authors' conclusion
In this novel study, we define the normative diagnostic criteria cut-offs in this unselected adolescent population and show that these cut-offs correspond to lower percentiles than conventional cut-offs. These findings highlight the pertinent need to re-define PCOS diagnostic cut-offs in adolescents. Validation is required in larger, multi-ethnic, and well-characterised adolescent cohorts.
Study context
- Population
- Adolescents from the Menstruation in Teenagers Study, a subgroup of the Raine Study; mean age at polycystic ovary syndrome (PCOS) assessment 15.2 years
- Participants
- 244 adolescents
- Outcome
- Normative cut-offs for mFG score, free testosterone, free androgen index and menstrual cycle length
Methodological detailsK-means cluster analysis, receiver operating characteristics curves, community-based
- K-means cluster analysis
- Receiver operating characteristics curves
- Community-based
Main finding
As reported in the abstract
Modified Ferriman-Gallwey (mFG) score cut-off (65th population percentile)
1.0
Free testosterone cut-off (71st population percentile)
23.4 pmol/L
Free androgen index (FAI) cut-off (70th population percentile)
3.6
Menstrual cycle length cut-off (59th population percentile)
29 days
Observational data: associations, not effects.
Original publication
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