Towards an individualized management of pubertal induction in girls with hypogonadism: insight into the best replacement outcomes from a large multicentre registry
Authors' conclusion
Our results provide evidence that progestins, hampering further changes in uterine volume and breast development, should be introduced only in the presence of a concomitant adequate 17β-oestradiol dose and an appropriate clinical response.
Study context
- Population
- Hypogonadal girls (chronological age > 10.9 years, Tanner stage ≤ 2) treated with transdermal 17β-oestradiol patches for at least 1 year49 completed induction
- Participants
- 95 participants
- Outcome
- Auxological and uterine outcomes of pubertal induction
- Follow-up
- End of induction
Methodological detailsmulticentre registry, longitudinal data, Induction started at median dose 0.14 mcg/kg/day with 6-monthly increase; completed when progesterone started with concomitant adult oestrogen dose
- Multicentre registry
- Longitudinal data
- Induction started at median dose 0.14 mcg/kg/day with 6-monthly increase; completed when progesterone started with concomitant adult oestrogen dose
Main finding
As reported in the abstract
end of induction
Final uterine longitudinal diameter (ULD) >65 mm
17/45 girls
Observational data: associations, not effects.
Original publication
Towards an individualized management of pubertal induction in girls with hypogonadism: insight into the best replacement outcomes from a large multicentre registry. Eur J Endocrinol. Published 26 May 2023. doi:10.
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