Reproductive endocrinology

Testosterone Treatment of Men with Unequivocal Hypogonadism Following Treatment of Organ-Confined Prostate Cancer

Endocr PractPublished Retrospective cohort study

Authors' conclusion

Testosterone treatment of men with unequivocal hypogonadism whose organ-confined prostate cancer is treated by radical prostatectomy may be safe.

Study context

Population
Men aged ≥50 years with unequivocal hypogonadism (≥1 morning serum testosterone ≤220 ng/dL before prostate cancer diagnosis) and organ-confined prostate cancer treated by radical prostatectomy, who resumed testosterone within 2 years after cancer treatmentof 269 screened
Participants
16 men
Outcome
Biochemical recurrence of prostate cancer (prostate-specific antigen ≥0.2 ng/mL)
Methodological detailselectronic medical record review, EMR search January 1, 2005, to September 20, 2021
  • Electronic medical record review
  • EMR search January 1, 2005, to September 20, 2021

Main finding

As reported in the abstract

Biochemical recurrence of prostate cancer · median 5 years (range, 1-20 years) of testosterone treatment and monitoring

Men with biochemical recurrence

0 of 16

Observational data: associations, not effects.

Further findings

Baseline serum testosterone range
9-185 ng/dL

Original publication

Testosterone Treatment of Men with Unequivocal Hypogonadism Following Treatment of Organ-Confined Prostate Cancer. Endocr Pract. Published 24 May 2023. doi:10.1016/j.eprac.2023.05.008

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