The Association between Inflammation, Testosterone and Sex Hormone Binding Globulin (SHBG) in men: A cross‐sectional Multi‐Ethnic Study of Atherosclerosis
An erratum to this article was published (Clin Endocrinol (Oxf), Mar 2026 ↗)
Authors' conclusion
Our results indicate that inflammatory markers have independent associations with levels of testosterone (total and bioavailable) and furthermore, appear to associate differently with SHBG levels.
Study context
- Population
- Men aged 45–84 years, Multi-Ethnic Study of Atherosclerosis3,041 analysed
- Participants
- 3,212 men
- Outcome
- Association of inflammatory markers (hsCRP, IL-6, sTNFR) with serum testosterone and SHBG
- Follow-up
- Baseline exam
Methodological detailsobservational, community-based, multivariable linear regression
- Observational
- Community-based
- Multivariable linear regression
Main finding
As reported in the abstract
Association of hsCRP with sex hormones, adjusted for confounders and IL-6
High sensitivity CRP (hsCRP) and total testosterone (B)
−0.14
hsCRP and bioavailable testosterone (B)
−0.06
hsCRP and SHBG (B)
−0.66
Observational data: associations, not effects.
Further findings
Association of IL-6 with sex hormones
- Similar results to hsCRP for testosterone; positive association with SHBG (B)
- 0.95
- Inverse association of IL-6 with bioavailable testosterone in African Americans and Hispanic Americans aged 45-54 years
Association of sTNFR with sex hormones
- No associations found for sTNFR and endogenous sex hormones
Original publication
The Association between Inflammation, Testosterone and SHBG in men: A cross‐sectional Multi‐Ethnic Study of Atherosclerosis. Clin Endocrinol (Oxf). Published 23 May 2023. doi:10.
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