A Randomized Controlled Trial Comparing Testosterone Enanthate and Testosterone Undecanoate as a Gender Affirming Hormonal Therapy in Trans Males
Authors' conclusion
Both TE and TU is safe, effective and well tolerated GAHT among FtM transsexuals with no significant differences in clinical, biochemical and hormonal parameters. Testosterone undecanoate was preferred at the end of 1 year due to its long dosing intervals.
Study context
- Population
- Testosterone-naive transgender men (female-to-male (FtM)), transgender multi-specialty clinic
- Participants
- 58 men
- Comparison
- Testosterone enanthate vs testosterone undecanoate
- Testosterone enanthate (TE)n = 29
- Testosterone undecanoate (TU)n = 29
Methodological detailsprospective, single-centre transgender multi-specialty clinic, Conducted over 28 months
- Prospective
- Single-centre transgender multi-specialty clinic
- Conducted over 28 months
Primary result
As reported in the abstract
Clinical, biochemical and hormonal parameters · 1 year
Number of injections received, TU vs TE
6 vs. 18
Original publication
A Randomized Controlled Trial Comparing Testosterone Enanthate and Testosterone Undecanoate as a Gender Affirming Hormonal Therapy in Trans Males. Clin Endocrinol (Oxf). Published 26 February 2025. doi:10.
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