Just as Tall on Testosterone; a Neutral to Positive Effect on Adult Height of GnRHa and Testosterone in Trans Boys
Authors' conclusion
During PS, growth decelerated followed by an acceleration during GAHT. Although adult height SD score was similar to baseline, adult height was taller than predicted based on BA at baseline, especially in those who started treatment at a younger BA. It is reassuring that PS and GAHT do not have a negative impact on adult height in transgender boys and might even lead to a slightly taller adult height, especially in those who start at a younger age.
Study context
- Population
- Transgender boys treated with GnRH analogues and testosterone who reached adult height; specialized gender identity clinic61 with bone age (BA) ≤14 years at start
- Participants
- 146 participants
- Exposure
- Puberty suppression (PS) with GnRHa followed by testosterone in trans boys
- Transgender boysn = 146
- Outcome
- Growth, bone age (BA), adult height, and difference between adult height and predicted adult height (PAH) and midparental height
- Follow-up
- Adult height
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Adult height (BA ≤14 years at start)
BA ≤14 years at start
172.0
± 6.9 · cm
- Height SD score vs baseline: similar
- 0.1 (95% CI, −0.2 to 0.4)
- Adult height above midparental height
- 3.9 ± 6.0 cm
- Adult height above predicted adult height (PAH) at start of PS
- 3.0 ± 3.6 cm
Observational data: associations, not effects.
Original publication
Just as Tall on Testosterone; a Neutral to Positive Effect on Adult Height of GnRHa and Testosterone in Trans Boys. J Clin Endocrinol Metab. Published 3 October 2022. doi:10.
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