Reproductive endocrinology

Variations in Volume: Breast Size in Trans Women in Relation to Timing of Testosterone Suppression

J Clin Endocrinol MetabPublished Cross-sectional study

Authors' conclusion

Early start of PS was not associated with larger breast volume, suggesting that pubertal testosterone exposure does not affect breast volume after subsequent GAHT. Despite limited breast size, most trans women were satisfied with their breast development.

Study context

Population
Trans women (aged 17–57 years) after 4.5 ± 1.7 years of gender-affirming hormone therapy (GAHT), tertiary gender identity clinic
Participants
60 women
Exposure
Early puberty suppression (PS) vs late PS vs GAHT in adulthood without prior PS
  • Early PSn = 23reference
  • Late PSn = 17
  • Adultn = 20
Outcome
Breast volume (3D scanner), adjusted for fat percentage
Methodological detailssingle-centre, tertiary gender identity clinic
  • Single-centre
  • Tertiary gender identity clinic

Main finding

As reported in the abstract

Breast volume
Difference, mL (95% CI)
Late PSvs Early PSlarger with late PS; unadjusted
47(−9 to 104)
Late PSvs Early PSafter correction for fat percentage
4(−67 to 75)
Adultvs Early PS
27(−28 to 83)
Adultvs Late PS
−20(−80 to 40)
Median breast volume, all participants (bra cup size < A)
115 mL (IQR, 68; 203)

Observational data: associations, not effects.

Further findings

Satisfied with breast size

Satisfied with breast size — Satisfied with breast size, total
68%

Original publication

Variations in Volume: Breast Size in Trans Women in Relation to Timing of Testosterone Suppression. J Clin Endocrinol Metab. Published 16 August 2024. doi:10.1210/clinem/dgae573

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