Sex Steroids Regulate Liver Fat Content and Body Fat Distribution in Both Men and Women: A Study in Transgender Persons
Authors' conclusion
Sex hormones regulate liver fat content and visceral fat in men and women.
Study context
- Population
- Transgender persons receiving hormone treatment, gender clinic in a hospital
- Comparison
- Gender-affirming hormone treatment, changes over time
- Trans womenn = 8
- Outcome
- Liver fat content, visceral and abdominal subcutaneous fat volume (magnetic resonance spectrometry or imaging)
- Follow-up
- Baseline, 6, 8, 18 and 58 weeks in trans women; baseline, 6 and 12 weeks in trans men with anastrozole; 52 weeks in trans men without anastrozole
Methodological details1-year follow-up, trans men randomized (anastrozole vs no anastrozole)
- 1-year follow-up
- Trans men randomized (anastrozole vs no anastrozole)
Main finding
As reported in the abstract
Trans women: change in liver fat content, week 58 vs week 6
decreased by 1.55%
−2.99 to −0.12
Trans men without anastrozole: change in liver fat content after 52 weeks
increased by 0.83%
0.14 to 1.52
Trans men without anastrozole: change in visceral fat volume after 52 weeks
increased by 34%
16 to 51
Original publication
Sex Steroids Regulate Liver Fat Content and Body Fat Distribution in Both Men and Women: A Study in Transgender Persons. J Clin Endocrinol Metab. Published 18 July 2023. doi:10.
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