Women with polycystic ovary syndrome (PCOS) have an increased risk for cardiovascular disease regardless of diagnostic criteria—a prospective population-based cohort study
Authors' conclusion
PCOS should be considered a significant risk factor for CVD. Future follow-up will show how the risk of CVD events develops after menopausal age.
Study context
- Population
- Women of the Northern Finland Birth Cohort 1966, followed from birth; PCOS classified at age 31, re-examined at age 46
- Exposure
- NIH-PCOS and Rotterdam-PCOS vs controls without PCOS features
- NIH-PCOSn = 144
- Rotterdam-PCOSn = 386
- Outcome
- Major adverse cardiovascular events (MACE): Myocardial infarction (MI), stroke, HF and cardiovascular mortality
- Follow-up
- Up to age 53
Methodological detailsNorthern Finland Birth Cohort 1966
- Northern Finland Birth Cohort 1966
Main finding
As reported in the abstract
MACE · 22-year follow-up
Each group vs controlsBMI-adjusted HR (CI)
Rotterdam-PCOS
2.33(1.26–4.30)
NIH-PCOS
2.47(1.18–5.17)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| MINIH-PCOS vs Controls · MI significantly more prevalent with NIH-PCOS | P = 0.010 |
| MIRotterdam-PCOS vs Controls · MI significantly more prevalent with Rotterdam-PCOS | P = 0.019 |
Original publication
Women with PCOS have an increased risk for cardiovascular disease regardless of diagnostic criteria—a prospective population-based cohort study. Eur J Endocrinol. Published 12 July 2023. doi:10.
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