WHAM—A Prospective Study of Weight and Body Composition After Risk-Reducing Bilateral Salpingo-oophorectomy
Authors' conclusion
24 months after RRSO, there was no difference in body weight compared with women who retained their ovaries. RRSO women gained more abdominal visceral adipose tissue than comparators, but there were no other differences in body composition. Use of HRT following RRSO had no effect on these outcomes.
Study context
- Population
- Premenopausal women at elevated risk of ovarian cancer planning risk-reducing salpingo-oophorectomy (RRSO), and comparators who retained their ovaries
- Participants
- 95 vs 99
- Exposure
- Risk-reducing salpingo-oophorectomy (RRSO) vs comparators who retained their ovaries
- RRSOn = 95
- Comparatorsn = 99reference
- Outcome
- Weight change
- Follow-up
- Baseline to 24 months
Methodological detailscomparison group retaining ovaries, DXA body composition subgroup
- Comparison group retaining ovaries
- DXA body composition subgroup
Main finding
Weight gain · 24 months
Mean difference
730 g
95% CI 920 g to 2380 g
P = 0.383
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Mean difference (g) (95% CI) | P value | |
|---|---|---|---|
| Weight, DXA body composition subgroup (54 RRSO, 81 comparators) · 24 monthsNo difference between groups | 944 (−1120 g to 2614 g) | P = 0.431 | |
| Abdominal visceral adipose tissue, body composition subgroup · 24 monthsMore with RRSO | 99.0 (8.8 g to 189.2 g) | P = 0.032 | |
| −2000020004000Difference, g (linear scale) |
Abdominal visceral adipose tissue, body composition subgroup · 24 months
- No other differences in body composition
Weight and body composition, hormone replacement therapy (HRT) users vs nonusers · 24 months
- No differences in weight or body composition between HRT users and nonusers
Original publication
WHAM—A Prospective Study of Weight and Body Composition After Risk-Reducing Bilateral Salpingo-oophorectomy. J Clin Endocrinol Metab. Published 6 July 2023. doi:10.
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