Long-term effects of premenopausal risk-reducing salpingo-oophorectomy on bone mineral density
Authors' conclusion
Premenopausal RRSO appears to be associated with long-term lowering of BMD Z-scores, emphasizing the importance of counseling women about bone health after premenopausal RRSO.
Study context
- Population
- Women at high familial risk of ovarian cancer who underwent risk-reducing salpingo-oophorectomy (RRSO), nationwide cohort
- Participants
- 493 vs 228
- Exposure
- Premenopausal RRSO vs postmenopausal RRSO
- Premenopausal RRSOn = 493
- Postmenopausal RRSOn = 228reference
- Outcome
- Bone mineral density (BMD) Z-scores of the lumbar spine (LS) and femoral neck (FN) by DXA
Methodological detailsnested in a nationwide cohort
- Nested in a nationwide cohort
Main finding
As reported in the abstract
BMD Z-scores (multivariable regression) · median 18.1 years after premenopausal RRSO
Β (lumbar spine (LS) Z-score)
−0.88
95% CI −1.10,−0.66
Premenopausal RRSO
Β (femoral neck (FN) Z-score)
−0.51
95% CI −0.71,−0.31
Premenopausal RRSO
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Z-score ≤ −1.0 (LS and FN, respectively) | RR (LS) 2.35 (95% CI 1.26–4.40) | |
| Z-score ≤ −1.0 (LS and FN, respectively) | RR (FN) 1.84 (95% CI 1.08–3.13) | |
| 0.20.5125Ratio (log scale) |
Age at study visit
P < 0.001
- Age at study visit — Median time since premenopausal RRSO, years (IQR 15.3-21.3)
- 18.1
Original publication
Long-term effects of premenopausal risk-reducing salpingo-oophorectomy on bone mineral density. Osteoporos Int. Published 4 October 2025. doi:10.
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