A Model Combining Testosterone, Androstenedione and Free Testosterone Index Improved the Diagnostic Efficiency of Polycystic Ovary Syndrome
Authors' conclusion
The model using Andro, TT, and FAI may help to identifying women with undiagnosed PCOS. Serum Andro is a meaningful biomarker for hyperandrogenism in PCOS patients and may further aid disease diagnosis.
Study context
- Population
- Women with hyperandrogenic polycystic ovary syndrome (PCOS) (Rotterdam criteria) and healthy controls, Shanghai Tenth People's Hospital
- Participants
- 139 vs 74
- Comparison
- Hyperandrogenic PCOS vs healthy controls; diagnostic performance of androstenedione (Andro) and other hormone indicators
- PCOSn = 139
- Controln = 74reference
- Outcome
- Diagnostic performance of Andro for PCOS
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
| Test or model | Youden index | Sensitivity | Specificity |
|---|---|---|---|
| Andro | 0.65 | 81.82% | 83.16% |
Andro
Youden index0.65
Sensitivity81.82%
Specificity83.16%
Further findings
Androgen levels, PCOS vs control
- Total testosterone (TT), Andro, dehydroepiandrosterone sulfate (DHEAS) and free androgen index (FAI) significantly higher in PCOS than control
Hormones, hyperandrostenedione vs normal Andro
- Andro, follicle-stimulating hormone (FSH), luteinizing hormone (LH), TT, FAI and LH/FSH higher in hyperandrostenedione than normal Andro
Correlations with Andro
- FSH, LH, TT, FAI, insulin sensitivity index and LH/FSH positively correlated with Andro
- Fasting blood glucose and 2-hour postprandial blood glucose negatively correlated with Andro
Original publication
A Model Combining Testosterone, Androstenedione and Free Testosterone Index Improved the Diagnostic Efficiency of Polycystic Ovary Syndrome. Endocr Pract. Published 22 May 2023. doi:10.
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