Nonobese PCOS Compared to Obese PCOS Have Similar Clinical Presentation, Hormonal Profile, and Insulin Resistance
Authors' conclusion
Obese and nonobese PCOS subjects overall appear to share similar biochemical hormonal correct VAT, and insulin resistance.
Study context
- Population
- Women 18–40 years of age with PCOS (grouped as obese and nonobese by ethnicity-based BMI and WC cut-offs) and controls without PCOS30 per group
- Participants
- 30 / 30 / 30 / 30
- Exposure
- Obese PCOS vs nonobese PCOS, with obese and nonobese controls without PCOS
- Obese PCOS (OP)n = 30
- Nonobese PCOS (NOP)n = 30
- OCn = 30reference
- NOCn = 30reference
- Outcome
- Hormonal profile, visceral fat, insulin resistance and cytokines: OP vs NOP
Main finding
As reported in the abstract
- Serum testosterone, LH/FSH, SHBG, visceral adipose tissue content, insulin resistance (disposition index on frequently sampled Intravenous Glucose Tolerance Test (fsIVGTT)) and pro-inflammatory cytokines (IL-6, IL-8, IL-1β) similar between OP and NOP
- Corrected VAT similar in OP vs NOP
Observational data: associations, not effects.
Further findings
| Outcome | OP | NOP | P value |
|---|---|---|---|
| Menstrual irregularitiesNOP vs OP | 70% | 93% | P = 0.02 |
| FPGOP vs NOP · slightly higher with OP | 89 mg/dl | 79 mg/dl | P = 0.02 |
- TNF-α (exception to similar cytokines) · between OP and NOP
- P = 0.001
- Body fat%, visceral fat and android gynoid ratio: PCOS vs BMI-matched controls · higher with PCOS
- P = < 0.001
- Hepatic fat content and insulin resistance: PCOS vs BMI-matched healthy controls · higher with PCOS
- p-value 0.03 (hepatic fat) and 0.02 (insulin resistance)
TNF-α (exception to similar cytokines)
- TNF-α differed between OP and NOP (17.7 vs. 11.5 pg/ml as printed, groups not assigned)
Original publication
Nonobese PCOS Compared to Obese PCOS Have Similar Clinical Presentation, Hormonal Profile, and Insulin Resistance. Clin Endocrinol (Oxf). Published 7 July 2025. doi:10.
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