Unraveling the Puzzle of Bone Health in Klinefelter Syndrome: Association Between DXA‐Derived Lumbar Bone Strain Index and Body Composition Parameters in a Single Center Cohort
Authors' conclusion
Increased adiposity may have detrimental effects on lumbar bone quality and strength as assessed by l-BSI in adult patients with KS. Later diagnosis of KS may contribute to unfavorable body composition and impaired skeletal health.
Study context
- Population
- Adults with 47,XXY Klinefelter syndrome followed at an Italian referral center; median age 39.5 years (range 18–61)
- Participants
- 44 adults
- Outcome
- Associations between lumbar bone strain index (l-BSI), TBS and body composition parameters by total body DXA
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Lumbar BSI (l-BSI) vs fat mass index (FMI), rho
0.64
p < 0.001
l-BSI vs fat-to-lean mass index ratio, rho
0.66
p < 0.001
l-BSI vs visceral fat mass, rho
0.56
p < 0.001
l-BSI vs trabecular bone score (TBS), strong negative correlation, rho
−0.73
p < 0.001
Observational data: associations, not effects.
Further findings
l-BSI by TBS status and age at klinefelter syndrome (KS) diagnosis
- Significantly higher l-BSI in patients with impaired TBS and with later age at KS diagnosis
- P < 0.001
- Later age at KS diagnosis correlated with higher body fat indexes
Original publication
Unraveling the Puzzle of Bone Health in Klinefelter Syndrome: Association Between DXA‐Derived Lumbar Bone Strain Index and Body Composition Parameters in a Single Center Cohort. Clin Endocrinol (Oxf). Published 6 July 2025. doi:10.
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