Body Composition by DXA in Patients with Klinefelter and Kallmann Syndrome: The Kama Study
Authors' conclusion
This study demonstrated a significant difference in lean mass between Klinefelter and Kallmann syndromes, supporting a potential role for FSH in modulating muscle mass independently of T levels.
Study context
- Population
- Patients with Klinefelter or Kallmann syndrome receiving T replacement therapy; body composition by whole-body DXA
- Participants
- 50 patients
- Exposure
- Klinefelter syndrome vs Kallmann syndrome
- Klinefeltern = 29
- Kallmannn = 21reference
- Outcome
- Prevalence of altered body composition parameters and comparison of body composition between the 2 groups
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
P < 0.001
- Radiologic sarcopenic obesity, all patients
- 7 (14%); 6/29 Klinefelter, 1/21 Kallmann
- Osteosarcopenic obesity, all patients (both Klinefelter)
- 2 (4%)
Observational data: associations, not effects.
Secondary outcomes
Association between follicle-stimulating hormone (FSH) levels and ALMI
- Univariable B
- −0.026; P = .002
- Adjusted for confounders B
- −0.030; P = .0022
- Inverse association
Original publication
Body Composition by DXA in Patients with Klinefelter and Kallmann Syndrome: The Kama Study. J Clin Endocrinol Metab. Published 10 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →