Different Glucose Variability in Women With Polycystic Ovary Syndrome With and Without Insulin Resistance: A Pilot Study
Authors' conclusion
Women with PCOS presented overall good glucose control. No differences in time in range and time in tight range were detected, but women with IR presented a lower CV.
Study context
- Population
- Women with polycystic ovary syndrome (PCOS) aged ≥18 years; median age 22 years [18–26], BMI 27.5 (6.6) kg/m²
- Participants
- 36 women
- Comparison
- PCOS with insulin resistance (IR) vs without IR
- Outcome
- CGM metrics (14 days CGM)
Main finding
As reported in the abstract
- Time in range (70-180 mg/dL) and time in tight range (70-140 mg/dL) comparable between women with and without IR (P > .05)
Further findings
| Outcome | IR | non-IR | P value |
|---|---|---|---|
| CV, IR defined by HOMA-IRLower CV with IR | 13.5 (range 11.2–15.5) | 17.1 (range 12.0–19.8) | P = 0.04 |
| CV, IR defined by quantitative insulin sensitivity check indexLower CV with IR | 13.8 (range 10.9–15.7) | 17.3 (range 11.2–19.9) | P = 0.04 |
Correlations of FSH with continuous glucose monitoring (CGM) metrics
- FSH correlated with mean sensor glucose, time above 140 mg/dL and GMI
Original publication
Different Glucose Variability in Women With Polycystic Ovary Syndrome With and Without Insulin Resistance: A Pilot Study. Endocr Pract. Published 2 July 2025. doi:10.
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