Nonclassical congenital adrenal hyperplasia: Metabolic and hormonal profile
Authors' conclusion
NCCAH women showed less adversely altered metabolic profile than PCOS women, but not as favourable as in the healthy controls. Optimisation of screening for metabolic and reproductive health may help to initiate the treatment and improve treatment outcomes.
Study context
- Population
- Untreated women with nonclassical congenital adrenal hyperplasia (NCCAH), women with PCOS and healthy regularly menstruating controls
- Participants
- 216 / 221 / 216
- Comparison
- NCCAH vs PCOS vs regularly menstruating controls
- NCCAHn = 216
- PCOSn = 221
- Controlsn = 216reference
- Outcome
- Metabolic and hormonal profiles of untreated women with NCCAH
Main finding
As reported in the abstract
- Higher BMI with NCCAH vs controls
- +7%
- Higher total cholesterol (TC) with NCCAH vs controls
- +34.1%
- Higher fasting glucose with NCCAH vs controls
- +18.9%
- Elevated testosterone with NCCAH vs controls
- 60.2%
- Elevated DHEAS with NCCAH vs controls
- 28.1%
- Elevated free androgen index with NCCAH vs controls
- 91.9%
- Elevated AMH with NCCAH vs controls
- 58%
Observational data: associations, not effects.
Secondary outcomes
Metabolic profile of PCOS vs controls
- Higher BMI with PCOS vs controls
- 18.9%
- Higher TC with PCOS vs controls
- +35.4%
- Higher triglycerides (TG) with PCOS vs controls
- +25%
- Higher fasting glucose with PCOS vs controls
- +22%
- Higher fasting insulin with PCOS vs controls
- +34.4%
- Higher homoeostatic model assessment for insulin resistance (HOMA-IR) with PCOS vs controls
- 36.2%
Insulin and HOMA-IR, NCCAH vs PCOS
- Lower insulin with NCCAH vs PCOS
- −28.5%
- Lower HOMA-IR with NCCAH vs PCOS
- −31.8%
Original publication
Nonclassical congenital adrenal hyperplasia: Metabolic and hormonal profile. Clin Endocrinol (Oxf). Published 23 November 2023. doi:10.
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