Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults
Authors' conclusion
This study shows that AIP was positively and non-linearly associated with the risk of prediabetes after adjusting for other confounding factors. When AIP ≤ 0.03, AIP was positively associated with the risk of prediabetes.
Study context
- Population
- Chinese adults at the Rich Healthcare Group, 2010–2016
- Participants
- 100,069 adults
- Exposure
- Atherogenic index of plasma (AIP) and risk of prediabetes
- Outcome
- Incident prediabetes
Main finding
As reported in the abstract
Prediabetes per AIP
AIP and prediabetes, adjusted HR
1.41
95% CI 1.31–1.52P < 0.0001
Observational data: associations, not effects.
Further findings
Nonlinearity: AIP inflection point (two-piecewise Cox model)
- Inflection point of AIP (P for log-likelihood ratio test < 0.001)
- 0.03
- HR when AIP ≤ 0.03
- 1.90 (95% CI 1.66-2.16; P < 0.0001)
- HR when AIP > 0.03, not significant
- 1.04 (95% CI 0.91-1.19; P = 0.5528)
Original publication
Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults. Cardiovasc Diabetol. Published 10 August 2023. doi:10.
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