Elevated urine albumin creatinine ratio increases cardiovascular mortality in coronary artery disease patients with or without type 2 diabetes mellitus: a multicenter retrospective study
Authors' conclusion
Even mildly increased uACR could increase the risk of cardiovascular mortality in patients with CAD, especially when combined with T2DM.
Study context
- Population
- Patients with coronary artery disease (CAD), with or without T2D
- Participants
- 5,960 patients
- Exposure
- Middle and high vs low baseline urine albumin creatinine ratio (uACR)
- Outcome
- Cardiovascular mortality and all-cause mortality
- Follow-up
- Median 2.2 [1.2-3.1] years
Methodological detailsmulticentre, registry
- Multicentre
- Registry
Main finding
As reported in the abstract
Cardiovascular mortality
Hazard ratio
2.32
Middle
Hazard ratio
3.22
High
Observational data: associations, not effects.
Further findings
| Outcome | HR |
|---|---|
| Cardiovascular mortality, patients without T2DMiddle vs Low | 2.33 |
| Cardiovascular mortality, patients without T2DHigh vs Low | 2.34 |
| Cardiovascular mortality, patients with T2DMiddle vs Low | 2.49 |
| Cardiovascular mortality, patients with T2DHigh vs Low | 3.98 |
All-cause mortality
- Higher risk with elevated vs low uACR
Original publication
Elevated urine albumin creatinine ratio increases cardiovascular mortality in coronary artery disease patients with or without type 2 diabetes mellitus: a multicenter retrospective study. Cardiovasc Diabetol. Published 10 August 2023. doi:10.
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