Evaluation of the role of atherogenic index of plasma in the reversion from Prediabetes to normoglycemia or progression to Diabetes: a multi-center retrospective cohort study
Authors' conclusion
Our study, for the first time, reveals a negative correlation between AIP and the reversion from prediabetes to normoglycemia and validates the crucial role of AIP in the risk assessment of prediabetes progression. Based on threshold analysis, therapeutically, keeping the AIP below 0.04 was of paramount importance for individuals with prediabetes aiming for reversion to NFG; preventatively, maintaining AIP below 0.17 was vital to reduce the risk of diabetes onset for those with prediabetes.
Study context
- Population
- Adults with prediabetes from 32 regions across 11 cities in China (Rich Healthcare Group medical examination institutions)
- Participants
- 15,421 adults
- Exposure
- Atherogenic index of plasma (AIP) and reversion to normal fasting glucose (NFG) or progression to diabetes
- Outcome
- Reversion from prediabetes to normal fasting glucose (NFG) or progression to diabetes
- Follow-up
- Median 2.9 years
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Reverted to NFG
6,481
42.03%
Progressed to diabetes
2,424
15.72%
AIP and progression to diabetes, HR
1.42 (1.24-1.64) (95% CI)
AIP and reversion to NFG, HR
0.89 (0.81-0.98) (95% CI)
Observational data: associations, not effects.
Further findings
Nonlinearity (restricted cubic spline (RCS)) and turning points of AIP
- Turning point for reversion to NFG
- 0.04
- Turning point for progression to diabetes
- 0.17
- Nonlinear relationship
Age subgroups
- AIP-associated risk of progression to diabetes relatively higher in younger populations; younger age favored reversion to NFG in relation to AIP
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →