Nonlinear association between atherogenic index of plasma and type 2 diabetes mellitus in overweight and obesity patients: evidence from Chinese medical examination data
Main finding · T2DM risk per AIP (adjusted)Result — go to the resultOdds ratio 3.18 95% CI 2.94–3.45Authors' conclusion
In overweight and obese individuals, the AIP was independently associated with T2DM, exhibiting a nonlinear association. Additionally, the association between the AIP and T2DM decreased with advancing age. Multiple types of inflammatory cells mediate this association.
Study context
- Population
- Overweight and obese individuals (body mass index (BMI) ≥ 24 kg/m²) screened January 2018 to December 2023 at Henan Provincial People's Hospital
- Participants
- 40,633 participants
- Exposure
- Atherogenic index of plasma (AIP) levels and T2DM in overweight and obese individuals
- Outcome
- Association between AIP and T2DM
Methodological detailssingle-centre medical examination data, multivariate logistic regression, generalized additive models, threshold effect analysis, mediation analysis
- Single-centre medical examination data
- Multivariate logistic regression
- Generalized additive models
- Threshold effect analysis
- Mediation analysis
Main finding
T2DM risk per AIP (adjusted)
Odds ratio
3.18
95% CI 2.94–3.45
Q4vs Q1
OR 3.18 (95% CI 2.94–3.45)
As reported in the abstract
- AIP associated with T2DM risk after adjustment, OR
- 5.17 (95% CI 4.69-5.69)
Observational data: associations, not effects.
Further findings
Subgroup by age
- Association between AIP and T2DM decreased with increasing age
- interaction P < 0.001
Nonlinear pattern
- J-shaped nonlinear association; significant increase in T2DM risk above AIP threshold
- AIP > - 0.07
Mediation by inflammatory cells
- Neutrophils mediated
- 4.66%
- Leukocytes mediated
- 4.16%
- Monocytes mediated
- 1.93%
Original publication
Nonlinear association between atherogenic index of plasma and type 2 diabetes mellitus in overweight and obesity patients: evidence from Chinese medical examination data. Cardiovasc Diabetol. Published 29 June 2024. doi:10.
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