Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study
Authors' conclusion
Elevated baseline AIP levels, medium stable trajectories and high stable trajectories are associated with an increased risk of T2DM in health screened adults.
Study context
- Population
- Adults undergoing health check-ups at Henan Provincial People's Hospital, January 2018–August 2024; Atherogenic Index of Plasma (AIP) = log(triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C))
- Participants
- 42,850 adults
- Exposure
- Baseline AIP quartiles and AIP trajectories in relation to T2D risk
- Outcome
- Incident T2D
- Follow-up
- Average 47.95 months
Methodological detailssingle-centre health check-up cohort, latent class trajectory modelling
- Single-centre health check-up cohort
- Latent class trajectory modelling
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Q4vs Q1
2.10(1.74–2.53)
Medium-stablevs Low-stable
1.72(1.50–1.96)
P < 0.05High-stablevs Low-stable
2.50(2.06–3.03)
P < 0.05- Participants developing T2D
- 3,228
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study. Cardiovasc Diabetol. Published 7 February 2025. doi:10.
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