Atherogenic index of plasma and its 5-year changes associated with type 2 diabetes risk: a 10-Year cohort study
Authors' conclusion
Our findings indicate that both baseline AIP levels and the 5-year changes in those levels are significantly associated with the risk of T2DM. Individuals with higher baseline AIP or 5-year increases in AIP were more likely to develop T2DM.
Study context
- Population
- Participants without baseline diabetes from a rural Chinese population; Atherogenic Index of Plasma (AIP) = log(TG/HDL-C)
- Participants
- 14,968 participants
- Exposure
- AIP quartiles 2–4 vs quartile 1; 5-year AIP increase or decrease vs stable
- Outcome
- Incident T2D
- Follow-up
- 10-year
Methodological details10-year follow-up, multivariable Cox regression, restricted cubic spline analyses
- 10-year follow-up
- Multivariable Cox regression
- Restricted cubic spline analyses
Main finding
As reported in the abstract
T2D by baseline AIP quartile · median follow-up 10.4 years
Adjusted hazard ratio (95% CI)P value
Q2vs Q1
1.17(1.00–1.38)
P < 0.0001for trendQ3vs Q1
1.38(1.18–1.62)
Q4vs Q1
1.96(1.68–2.29)
- Participants developing T2D
- 2,165
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| T2D by 5-year change in AIPIncreasedvs Stable18% higher risk | 1.18 (1.00–1.40) | |
| T2D by 5-year change in AIPDecreasedvs Stable20% reduction in risk | 0.80 (0.67–0.95) | |
| 0.512Adjusted hazard ratio (log scale) |
Dose–response (RCS) with T2D risk
- Linear relationship, baseline AIP
- p for nonlinearity = 0.927
- Linear relationship, 5-year AIP change
- p for nonlinearity = 0.083
Original publication
Atherogenic index of plasma and its 5-year changes associated with type 2 diabetes risk: a 10-Year cohort study. Cardiovasc Diabetol. Published 25 August 2025. doi:10.
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