Lipids & metabolic liver disease
Non‐fasting lipids and cardiovascular disease in those with and without diabetes in Alberta's Tomorrow Project: A prospective cohort study
Authors' conclusion
Elevated non-fasting RC predicted increased CVD risk in middle and older-aged adults without diabetes; similar trends were observed in participants with diabetes and require further testing in a larger sample.
Study context
- Population
- Alberta's Tomorrow Project participants without prevalent cardiovascular disease (CVD) or incident diabetes, with complete non-negative non-fasting lipid data and TG <4.5 mmol/L; 69.8% women, mean age 61.6 ± 9.7 years, 6.5% prevalent diabetes
- Participants
- 13,631 participants
- Exposure
- Non-fasting remnant cholesterol and incident CVD, by diabetes status
- Outcome
- Incident CVD in relation to non-fasting RC
Methodological detailslinked to administrative health records, Cox proportional hazards regression stratified by diabetes status
- Linked to administrative health records
- Cox proportional hazards regression stratified by diabetes status
Main finding
As reported in the abstract
Incident CVD per non-fasting RC
Adjusted hazard ratio (95% CI)P value
No diabetesRC associated with increased CVD risk
1.22(1.03–1.43)
P = 0.02Diabetessimilar trend, not statistically significant
1.31(0.84–2.05)
P = 0.23Per non-fasting RC, as printed
Observational data: associations, not effects.
Further findings
Non-fasting RC · higher with diabetes
P < 0.0001
Original publication
Non‐fasting lipids and cardiovascular disease in those with and without diabetes in Alberta's Tomorrow Project: A prospective cohort study. Diabet Med. Published 30 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →