Lipids & metabolic liver disease
The atherogenic index of plasma and carotid atherosclerosis in a community population: a population-based cohort study in China
An erratum to this article was published (Cardiovasc Diabetol, 7 Sep 2023 ↗)
Authors' conclusion
An elevated AIP in a community-based population is associated with a higher rate of CA. the AIP could serve as a potential biomarker for CA risk assessment.
Study context
- Population
- Community residents aged ≥40 years who underwent cervical vascular US, December 2017 to December 2020, Hunan, China
- Participants
- 52,380 residents
- Exposure
- Atherogenic index of plasma (AIP) quartiles and per 1-SD increase in AIP
- Outcome
- Carotid atherosclerosis (CA), increased carotid intima-media thickness (CIMT), plaques and stenosis
Methodological detailspopulation-based, community-based
- Population-based
- Community-based
Main finding
As reported in the abstract
CA, increased CIMT and plaques
Odds ratio (95% CI)
Per 1-SD increase in AIPCA; adjusted for traditional risk factors
1.06(1.04–1.08)
Per 1-SD increase in AIPincreased CIMT; adjusted for traditional risk factors
1.07(1.05–1.09)
Per 1-SD increase in AIPplaques; adjusted for traditional risk factors
1.04(1.02–1.06)
Q4vs Q1CA
1.18(1.12–1.25)
Q4vs Q1increased CIMT
1.20(1.13–1.26)
Q4vs Q1plaques
1.13(1.06–1.19)
- AIP · stenosis; no association observed
- 0.97 (95% CI 0.77–1.23); P for trend = 0.758
Observational data: associations, not effects.
Further findings
Subgroup analyses
- More significant association between AIP and carotid atherosclerosis (CA) in younger subjects (aged < 60 years) with body mass index (BMI) ≥ 24 and fewer comorbidities
Incremental predictive value for CA over established risk factors
- Improvement in net reclassification index (NRI) and integrated discrimination index (IDI)
- all P < 0.05
Original publication
The atherogenic index of plasma and carotid atherosclerosis in a community population: a population-based cohort study in China. Cardiovasc Diabetol. Published 27 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →