Lipids & metabolic liver disease
U-shaped association between the triglyceride–glucose index and atrial fibrillation incidence in a general population without known cardiovascular disease
Authors' conclusion
A U-shaped association between the TyG index and AF incidence is observed in Americans without known cardiovascular diseases. Female sex may be a modifier in the association between the TyG index and AF incidence.
Study context
- Population
- Individuals without known CVD (HF, coronary heart disease or stroke) from the Atherosclerosis Risk in Communities (ARIC) cohort; mean age 54.0 years, 55.6% female
- Participants
- 11,851 individuals
- Exposure
- Triglyceride-glucose (TyG) index categories vs middle category
- Outcome
- Incident AF
- Follow-up
- Median 24.26 years
Methodological detailsARIC cohort, multivariable-adjusted Cox regression
- ARIC cohort
- Multivariable-adjusted Cox regression
Main finding
As reported in the abstract
Each group vs TyG 8.80-9.20Adjusted hazard ratio (95% CI)
TyG <8.80
1.15(1.02–1.29)
TyG >9.20
1.18(1.03–1.37)
- Incident atrial fibrillation (AF) cases
- 1925 (0.78/per 100 person-years)
- Exposure-effect analysis confirmed U-shaped association between TyG index and AF incidence
- P = 0.041
- Increased AF incidence with graded TyG index (Kaplan-Meier)
- P < 0.001
Observational data: associations, not effects.
Further findings
Sex-specific analysis
- U-shaped association between TyG index and incident AF still existed in females but not in males
Original publication
U-shaped association between the triglyceride–glucose index and atrial fibrillation incidence in a general population without known cardiovascular disease. Cardiovasc Diabetol. Published 18 May 2023. doi:10.
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