Lipids & metabolic liver disease
Remnant Cholesterol Independently Predicts the Development of Nonalcoholic Fatty Liver Disease
Main finding · Incident NAFLDResult — go to the resultHazard ratio 2.824 95% CI 2.268–3.517Authors' conclusion
Serum levels of remnant cholesterol have predictive value for the development of NAFLD beyond traditional lipid profiles.
Study context
- Population
- Adults undergoing annual physical examination1,339 incident nonalcoholic fatty liver disease (NAFLD) cases
- Participants
- 9,184 adults
- Exposure
- Remnant cholesterol quartiles
- Outcome
- Incident NAFLD
- Follow-up
- 31 662 person-years of follow-up
Methodological detailsannual physical examination cohort, Cox proportional hazards regression, multivariable-adjusted
- Annual physical examination cohort
- Cox proportional hazards regression
- Multivariable-adjusted
Main finding
As reported in the abstract
Hazard ratio
2.824
95% CI 2.268–3.517
P < 0.001
Q4vs Q1
HR 2.824 (95% CI 2.268–3.517); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident NAFLD among individuals with normal LDL-C, HDL-C and TGAssociation remained significant | 1.929 (1.291–2.882) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Incident NAFLD among individuals achieving LDL-C and non-HDL-C treatment targets
- Association between remnant cholesterol and incident NAFLD was still significant
Original publication
Remnant Cholesterol Independently Predicts the Development of Nonalcoholic Fatty Liver Disease. J Clin Endocrinol Metab. Published 15 May 2023. doi:10.
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