Nocturnal hypoxemic burden and micro- and macrovascular disease in patients with type 2 diabetes
Authors' conclusion
While hypoxemic burden due to oxygen desaturations and the magnitude of desaturation depth were significantly associated with CKD, only severe hypoxemic burden due to non-specific drifts was associated with CVD. Specific types of hypoxemic burden may be related to micro- and macrovascular disease.
Study context
- Population
- Patients with T2D enrolled in the DIACORE (DIAbetes COhoRtE) study, with overnight oximetry
- Participants
- 1,247 patients
- Exposure
- Long T90 vs lower hypoxemic burden
- Outcome
- Association of hypoxemic burden parameters (T90, T90non-specific, T90desaturation, desaturation depth) with CKD (microvascular disease) and a composite of CVD (macrovascular disease)
Main finding
As reported in the abstract
Long T90
CKD 38%; CVD 30%
Lower hypoxemic burden
CKD 28%; CVD 21%
P < 0.001 (chronic kidney disease (CKD)); p < 0.001 (CVD)
- Desaturation depth and CKD, OR (95% CI [1.06; 1.61]), p = 0.013
- 1.30
- T90non-specific [Q3;Q4] vs [Q1;Q2] and CVD, adjusted OR (95% CI [1.12; 2.05]), p = 0.008
- 1.51
Observational data: associations, not effects.
Original publication
Nocturnal hypoxemic burden and micro- and macrovascular disease in patients with type 2 diabetes. Cardiovasc Diabetol. Published 6 June 2024. doi:10.
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