Cerebellar gray matter and white matter damage among older adults with prediabetes
Authors' conclusion
Cerebellar injury had already appeared in the prediabetic stage, and cerebellar injury was aggravated in the diabetic stage; therefore, the cerebellum is a key area that is damaged early in the development of diabetes.
Study context
- Population
- Older adults with normal glucose metabolism, prediabetes or T2D; cerebral and cerebellar MRI (T1-weighted, T2-weighted FLAIR, diffusion tensor imaging)
- Participants
- 78 / 92 / 108
- Exposure
- Prediabetes and T2D vs normal glucose metabolism
- Normal glucose metabolismn = 78reference
- Prediabetesn = 92
- T2Dn = 108
- Outcome
- Cerebral and cerebellar gray matter volume, white matter volume, white matter microstructure and white matter hyperintensity
Main finding
As reported in the abstract
Cerebral and cerebellar structure
- Prediabetes: significant gray matter and white matter atrophy, microstructural damage in cerebellar and cerebral regions
- T2D: widespread structural alterations
Observational data: associations, not effects.
Further findings
Function of damaged brain areas (Neurosynth decoding)
- Cerebellar area damaged in prediabetes closely related to motor function; area affected by diabetes related to complex cognitive function in addition to motor function
Original publication
Cerebellar gray matter and white matter damage among older adults with prediabetes. Diabetes Res Clin Pract. Published 6 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →