No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts
Main finding · T1D in offspringResult — go to the resultPooled hazard ratio 1.00 95% CI 0.88–1.14Authors' conclusion
Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in offspring should not be prioritised.
Study context
- Population
- Mother-child pairs in the Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa); T1D in children from national diabetes registriesT1D in children 634
- Participants
- 153,843 mother-child pairs
- Exposure
- Higher vs lower maternal eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) intake during pregnancy
- Outcome
- T1D in offspring
Methodological detailstwo pooled pregnancy cohorts (DNBC, MoBa), validated food frequency questionnaires, registry-ascertained outcome
- Two pooled pregnancy cohorts (DNBC, MoBa)
- Validated food frequency questionnaires
- Registry-ascertained outcome
Main finding
As reported in the abstract
Pooled hazard ratio
1.00
95% CI 0.88–1.14
Sum of EPA and DHA intake during pregnancy (per g/day)
pooled HR 1.00 (95% CI 0.88–1.14)
Per g/day, as printed
Observational data: associations, not effects.
Further findings
- Robustness analyses gave very similar results
Original publication
No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts. Diabetologia. Published 19 March 2024. doi:10.
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