Elevated Serum IgA at Onset of Type 1 Diabetes in Children
Authors' conclusion
Elevated serum IgA is present in 20.3% of the children at T1D onset and is associated with specific demographic and clinical characteristics, suggesting a unique pathogenesis in a subset of individuals. Further studies are warranted to investigate the IgA response, its role in T1D pathogenesis, and whether these associations persist over time.
Study context
- Population
- Racially diverse children (6 months-18 years) with T1D with serum IgA measured within 90 days of diagnosis
- Participants
- 631 children
- Exposure
- Elevated vs normal serum IgA
- Elevated IgAn = 128
- Outcome
- Prevalence of elevated serum IgA at onset of pediatric T1D and associated characteristics
- Follow-up
- Within 90 days of T1D diagnosis
Methodological detailsunivariable and multivariable logistic regression
- Univariable and multivariable logistic regression
Main finding
As reported in the abstract
Prevalence of elevated serum IgA at T1D onset
Elevated IgA
20.3%
128
Observational data: associations, not effects.
Further findings
Characteristics associated with elevated serum IgA (multivariable, adjusted)
- Positive IAA, OR
- 1.653 (95% CI 1.019-2.679; p=0.041)
- Higher HbA1c, OR
- 1.132 (95% CI 1.014-1.268; p=0.029)
- Hispanic ethnicity, OR
- 3.279 (95% CI 2.003-5.359; p < 0.001)
- Glutamic acid decarboxylase autoantibodies (GADA) positivity, OR
- 0.474 (95% CI 0.281-0.805; p=0.005)
- Adjusted for confounders
Original publication
Elevated Serum IgA at Onset of Type 1 Diabetes in Children. Pediatr Diabetes. Published 19 March 2024. doi:10.
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