HLA Class II (DR, DQ, DP) Genes Were Separately Associated With the Progression From Seroconversion to Onset of Type 1 Diabetes Among Participants in Two Diabetes Prevention Trials (DPT-1 and TN07)
Authors' conclusion
These results suggest that HLAII polymorphisms influence progression from islet autoimmunity to T1D among at-risk subjects with islet autoantibodies.
Study context
- Population
- Participants with islet autoantibodies from the Diabetes Prevention Trial-1 and TrialNet Oral Insulin trial (TN07)
- Participants
- 1,216 participants
- Comparison
- HLA class II haplotypes and progression from islet autoimmunity to T1D
- Primary endpoint
- Progression from islet autoimmunity (asymptomatic) to symptomatic T1D
Methodological detailssecondary analysis of the DPT-1 and TN07 diabetes prevention trials, next-generation targeted sequencing, Cox regression
- Secondary analysis of the DPT-1 and TN07 diabetes prevention trials
- Next-generation targeted sequencing
- Cox regression
Primary result
As reported in the abstract
Progression to T1D by HLA class II haplotype
- DQA1*03:01-DQB1*03:02, HR (P = 3.50*10-3)
- 1.25
- DQA1*03:03-DQB1*03:01, HR (P = 1.16*10-3)
- 0.56
- DQA1*05:01-DQB1*02:01, HR (P = 0.041)
- 1.19
- DPA1*02:01-DPB1*11:01, HR adjusted for DQ (P = 0.021)
- 1.98
- DPA1*01:03-DPB1*03:01, HR adjusted for DQ (P = 6.16*10-3)
- 0.70
- DRB1*03:01-DRB3*01:01, HR (P = 0.04)
- 0.73
- DRB1*03:01-DRB3*02:02, HR (P = 0.019)
- 1.44
- DRB1*12:01-DRB3*02:02, HR (P = 0.018)
- 2.6
- DRB1*01:03 alone, HR (P = 0.039)
- 2.32
Original publication
HLA Class II (DR, DQ, DP) Genes Were Separately Associated With the Progression From Seroconversion to Onset of Type 1 Diabetes Among Participants in Two Diabetes Prevention Trials (DPT-1 and TN07). Diabetes Care. Published 18 March 2024. doi:10.
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