Parental history of psychiatric disorders and risk of type 1 diabetes in the offspring
Main finding · T1D in offspringResult — go to the resultIncidence relative risk 1.10 95% CI 1.01–1.20Authors' conclusion
Our results do not support a strong genetic link between psychiatric conditions and T1DM. However, the risks of offspring T1DM were increased in subgroups of female offspring and in offspring of mothers with a history of eating disorder or obsessive-compulsive disorder, independent of heredity for T1DM, which may warrant further investigation in future studies.
Study context
- Population
- All children born in Sweden in 1997–2016 and their parents, followed from birth until 31 Dec 20177,794 T1D cases
- Participants
- 1,497,949 children
- Exposure
- Parental psychiatric history at child's birth vs none
- Outcome
- T1D in offspring
- Follow-up
- From birth until 31 Dec 2017
Methodological detailsnational registers, Poisson regression
- National registers
- Poisson regression
Main finding
As reported in the abstract
Incidence relative risk
1.10
95% CI 1.01–1.20
Observational data: associations, not effects.
Further findings
Paternal psychiatric diagnoses or diagnoses assigned after delivery
- Not associated with increased T1D risk
Maternal eating disorder and offspring T1D
- RR, independent of parental T1D
- 1.53 [1.17-2.00]
Maternal obsessive-compulsive disorder and offspring T1D
- RR, independent of parental T1D
- 1.62 [1.02-2.58]
Original publication
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