Maternal autoimmune disease associated with a higher risk of offspring with type 1 diabetes: A nationwide mother-child cohort study in Taiwan
Main finding · Childhood-onset T1DResult — go to the resultAdjusted hazard ratio 1.55 95% CI 1.16–2.08Authors' conclusion
This nationwide mother and child cohort study showed a higher risk of type 1 diabetes in the children whose mothers had autoimmune disease, including Hashimoto's thyroiditis, and inflammatory bowel diseases.
Study context
- Population
- Newborns from the Taiwan Maternal and Child Health Database, born 2009–2016, followed to December 31, 2019
- Participants
- 1,288,347 newborns
- Exposure
- Maternal autoimmune disease vs no maternal autoimmune disease
- Outcome
- Childhood-onset T1D
- Follow-up
- To December 31, 2019
Methodological detailsmultivariable Cox regression
- Multivariable Cox regression
Main finding
As reported in the abstract
Adjusted hazard ratio
1.55
95% CI 1.16–2.08
Maternal autoimmune diseasevs No maternal autoimmune disease
aHR 1.55 (95% CI 1.16–2.08)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Childhood-onset T1D by maternal autoimmune disease typeMaternal T1Dvs No maternal autoimmune diseaseMultivariable model | 11.33 (4.62–27.77) | |
| Childhood-onset T1D by maternal autoimmune disease typeMaternal Hashimoto's thyroiditisvs No maternal autoimmune diseaseMultivariable model | 3.73 (1.70–8.15) | |
| Childhood-onset T1D by maternal autoimmune disease typeMaternal inflammatory bowel diseasesvs No maternal autoimmune diseaseMultivariable model | 2.00 (1.07–3.76) | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Original publication
Maternal autoimmune disease associated with a higher risk of offspring with type 1 diabetes: A nationwide mother-child cohort study in Taiwan. Diabetes Metab. Published 25 March 2023. doi:10.
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