The effect of age at onset of type 1 diabetes mellitus on epilepsy vulnerability
Main finding · Epilepsy incidence rateResult — go to the resultFold higher incidence rate 2.26Authors' conclusion
There is age-related vulnerability to epilepsy following type 1 diabetes onset. Adulthood-onset type 1 diabetes is an independent risk factor for epilepsy susceptibility after type 1 diabetes.
Study context
- Population
- Patients with T1D with onset age ≤ 40 years enrolled in the Taiwan National Health Insurance program
- Participants
- 6,165 patients
- Exposure
- Adulthood-onset vs childhood-onset T1D
- Adulthood-onsetn = 2,594
- Childhood-onsetn = 3,571reference
- Outcome
- Epilepsy incidence
- Follow-up
- 8.6 years median
Methodological detailspopulation-based, longitudinal, Taiwan National Health Insurance data
- Population-based
- Longitudinal
- Taiwan National Health Insurance data
Main finding
Epilepsy incidence rate
Fold higher incidence rate
2.26
As reported in the abstract
Observational data: associations, not effects.
Further findings
Epilepsy IRR by onset age
- IRR lowest with onset age 6-12 years vs ≤ 6 years; highest with onset age 30-40 years
Follow-up duration in adulthood-onset
- Longer follow-up correlates with higher epilepsy risk in adulthood-onset group
Independent risk factors for epilepsy (multiple logistic regression)
- Onset age 30-40 years, male, >1 DKA episode and unprovoked seizure events were independent risk factors
Original publication
The effect of age at onset of type 1 diabetes mellitus on epilepsy vulnerability. Diabetes Res Clin Pract. Published 22 March 2023. doi:10.
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