Hypoglycemia and glycemic variability of people with type 1 diabetes with lower and higher physical activity loads in free-living conditions using continuous subcutaneous insulin infusion with predictive low-glucose suspend system
Authors' conclusion
Active people with T1D are able to maintain glycemic variability, TIR and TAR within recommended values regardless of PA loads. However, the high prevalence of TBR and the less use of post-PA management strategies highlights the potential need to increase awareness on actions to avoid glycemic excursions and hypoglycemia after exercise completion.
Study context
- Population
- Active adults with T1D on CSII with predictive low glucose suspend and glucose monitoring (age 35±10 years; diabetes duration 21±11 years; BMI 24.8±3.4 kg/m²; HbA1c 6.9±0.6%)equally divided
- Participants
- 28 adults
- Exposure
- Higher vs lower physical activity (PA) load
- Outcome
- Glycemic variability and time in ranges
- Follow-up
- 14 days
Methodological detailsfree-living conditions, accelerometer-tracked over 14 days
- Free-living conditions
- Accelerometer-tracked over 14 days
Main finding
As reported in the abstract
- Higher coefficient of variation (CV) in sedentary vs active hours in lower load (LL)
- p≤0.05
- Increased mean amplitude of glycemic excursions (MAGE) during nighttime vs daytime in higher load (HL)
- p≤0.05
Observational data: associations, not effects.
Further findings
Diabetes management strategies · during vs post-PA
- All participants used fewer post-PA management strategies than during PA
- P ≤ 0.05
- Self-reported
Original publication
Hypoglycemia and glycemic variability of people with type 1 diabetes with lower and higher physical activity loads in free-living conditions using continuous subcutaneous insulin infusion with predictive low-glucose suspend system. BMJ Open Diabetes Res Care. Published 21 March 2023. doi:10.
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