Longitudinal Magnetic Resonance Imaging (MRI) Shows Progressive Decline in Pancreas Size and Altered Pancreas Shape in Type 1 Diabetes
Authors' conclusion
Pancreas size declines most rapidly near the clinical diagnosis of T1D and continues to decline throughout adulthood. Declines in pancreas size are accompanied by changes in pancreas shape.
Study context
- Population
- Individuals with T1D and controls undergoing pancreas MRI, academic medical center, 2014–202253 with longitudinal MRI
- Participants
- 91 vs 90
- Exposure
- T1D vs controls
- T1Dn = 91
- Controlsn = 90reference
- Outcome
- Pancreas size and shape measured from MRI
Methodological detailssingle academic medical center, longitudinal MRI, cross-sectional analysis
- Single academic medical center
- Longitudinal MRI
- Cross-sectional analysis
Main finding
As reported in the abstract
- Pancreas volume and pancreas volume index normalized for body weight declined during the first year after diagnosis
- Pancreas volume index continued to decline through the fifth year after diagnosis
- Pancreas shape altered in T1D and further diverged from controls over the first 5 years after diagnosis
Observational data: associations, not effects.
Further findings
Cross-sectional pancreas size (diabetes duration up to 60 years)
- Pancreas size in adults with T1D negatively correlated with age and disease duration; pancreas volume and volume index stable in controls
Pancreas volume index and glycemic variability
- Pancreas volume index correlated inversely with low blood glucose index (hypoglycemia risk)
Nondiabetic individuals at genetic risk for T1D
- Pancreas size and shape altered
Discrimination of T1D from controls
- Combined size and shape analysis better distinguished T1D from controls than size alone
Original publication
Longitudinal MRI Shows Progressive Decline in Pancreas Size and Altered Pancreas Shape in Type 1 Diabetes. J Clin Endocrinol Metab. Published 20 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →