Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes
Authors' conclusion
These findings suggest that measures of pancreas volume and metabolism reflect distinct components of risk for developing stage 3 type 1 diabetes and that a combination of these measures may provide superior prediction than either alone.
Study context
- Population
- Multiple autoantibody-positive participants in the Type 1 Diabetes TrialNet Pathway to Prevention study
- Participants
- 65 participants
- Exposure
- Pancreas volume index (PVI) vs oral glucose tolerance testing (OGTT)-derived metabolic scores (Index60, DPTRS) vs PVI plus DPTRS for predicting progression to stage 3 T1D
- Outcome
- Prediction of progression to stage 3 T1D
- Follow-up
- Measurements at study entry
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
AUC for predicting progression to stage 3 T1D · study entry
| Group | AUC |
|---|---|
| PVI | 0.76 |
| Index60 | 0.79 |
| DPTRS | 0.79 |
| PVI plus DPTRS | 0.91 |
AUC
PVI0.76
Index600.79
DPTRS0.79
PVI plus DPTRS0.91
Observational data: associations, not effects.
Further findings
PVI, Index60 and DPTRS at study entry: progressors (n=11) vs non-progressors (n=54)
- PVI, Index60 and DPTRS all significantly different in progressors vs non-progressors
- P < 0.005
Correlation of PVI with metabolic testing
- PVI did not correlate with metabolic testing
Longitudinal change in progressors
- PVI declined longitudinally in the 11 individuals diagnosed with stage 3 T1D, whereas Index60 and DPTRS increased
Original publication
Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes. Diabetes Care. Published 27 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →