HOMA-IR and the Matsuda Index as predictors of progression to type 1 diabetes in autoantibody-positive relatives
Authors' conclusion
Progression to Stages 2 and 3 of type 1 diabetes increases with HOMA-IR and decreases with the Matsuda Index after adjustments for insulin secretion. Indicators of insulin secretion appear helpful for interpreting associations of progression to type 1 diabetes with HOMA-IR or the Matsuda Index in AAb-positive relatives.
Study context
- Population
- AAb-positive relatives of individuals with T1D, TrialNet Pathway to Prevention
- Participants
- 6,256 relatives
- Exposure
- Tertiles of HOMA-IR and Matsuda Index, adjusted for insulin secretion
- Outcome
- Transitions through stages of T1D: Not Staged to Stage 1, Stage 1 to Stage 2, and progression to Stage 3
Methodological detailsCox regression, tertiles of HOMA-IR and Matsuda Index
- Cox regression
- Tertiles of HOMA-IR and Matsuda Index
Main finding
As reported in the abstract
Stage 1 to Stage 2, HOMA-IR: HR
1.71
p<0.0001
Stage 1 to Stage 2, Matsuda Index: HR
0.40
p<0.0001
Stages 1 or 2 to Stage 3, HOMA-IR: HR
1.98
p<0.0001
Stages 1 or 2 to Stage 3, Matsuda Index: HR
0.46
p<0.0001
Observational data: associations, not effects.
Further findings
Association of HOMA-IR and Matsuda Index with baseline age and BMI percentile (BMIp)
- Strong associations of HOMA-IR (positive) and Matsuda Index (inverse) with baseline age and BMIp
- P < 0.0001
Progression to Stage 3 without adjustments
- Without adjustments, associations were inverse for HOMA-IR and positive for Matsuda Index, opposite in directionality to adjusted
- Unadjusted
Original publication
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