Impact of Preeclampsia and Parity on Sex-based Discrepancies in Subclinical Carotid Atherosclerosis in Type 1 Diabetes
Authors' conclusion
The risk for carotid plaque in women compared with men decreased as exposure to obstetric factors diminished. However, the addition of these factors did not improve the prediction of the Steno-Risk.
Study context
- Population
- People with T1D (48.5% women) without CVD and age ≥40 years, nephropathy, and/or ≥10 years of diabetes duration with another risk factor48.5% women
- Participants
- 728 people
- Exposure
- Women by obstetric history vs men
- Outcome
- Carotid plaque by US and cardiovascular risk estimated by the Steno T1 Risk Engine (Steno-Risk)
Methodological detailssingle tertiary hospital
- Single tertiary hospital
Main finding
As reported in the abstract
Carotid plaque
Each group vs menAdjusted odds ratio (95% CI)
Nulliparous women
.48(.28-.82)
Women without preeclampsia
.51(.33-.79)
Observational data: associations, not effects.
Further findings
| Outcome | Men | Nulliparous women | Women without preeclampsia | Preeclampsia | P value |
|---|---|---|---|---|---|
| AUC of Steno-Risk for identifying ≥2 carotid plaquesPreeclampsia vs Men · AUC lower in the preeclampsia group | .7886 | .9026 | .8230 | .7841 | P between groups = .042 |
Prevalence of carotid plaque by estimated cardiovascular risk
- Prevalence of carotid plaque increased with estimated cardiovascular risk in all subgroups except the preeclampsia group
Adding parity or preeclampsia to Steno-Risk
- Neither addition led to a statistically significant increase in AUC
Original publication
Impact of Preeclampsia and Parity on Sex-based Discrepancies in Subclinical Carotid Atherosclerosis in Type 1 Diabetes. J Clin Endocrinol Metab. Published 27 December 2023. doi:10.
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