Association of obesity- and insulin resistance-related indices with subclinical carotid atherosclerosis in type 1 diabetes: a cross-sectional study
Authors' conclusion
Among various OIRIs, CVAI shows the strongest association with SCA in adults with T1D. These findings suggest that CVAI may merit further longitudinal investigation as a potential marker for SCA assessment in this population.
Study context
- Population
- Adult inpatients with classic T1D admitted October 2008 to June 2021, First Affiliated Hospital of Air Force Medical University, Xi'an, China
- Participants
- 418 inpatients
- Exposure
- Obesity- and insulin resistance-related indices (OIRIs) and subclinical carotid atherosclerosis (SCA)
- Outcome
- Association of OIRIs with SCA
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Chinese visceral adiposity index (CVAI), OR
1.68, 1.16-2.47
95% CI
eGDRWHR (estimated glucose disposal rate (eGDR) calculated with waist-to-hip ratio (WHR)), OR
0.44, 0.22-0.82
95% CI
eGDRWC (eGDR calculated with waist circumference), OR
0.49, 0.24-0.93
95% CI
Observational data: associations, not effects.
Further findings
Diagnostic performance for SCA
- CVAI highest AUC
- 0.73 (0.69-0.77) (95% CI)
Shape of association (restricted cubic spline (RCS))
- Linear and positive association between CVAI and SCA in the overall population and in females
- Subgroup and sensitivity analyses supported the CVAI–SCA association
Adding CVAI to Steno Type 1 Risk Engine (ST1RE)
- Improved reclassification but did not enhance overall discriminative ability to identify SCA
Original publication
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