Effect of vitamin D supplementation on glycemic control in children and adolescents with type 1 diabetes mellitus: Data from a controlled clinical trial
Authors' conclusion
Oral cholecalciferol supplementation was effective in correcting VDD. This study identified the minimal effect of this intervention on glycemic control.
Study context
- Population
- Children and adolescents with T1D for at least one year
- Participants
- 133 children
- Comparison
- Oral cholecalciferol 2000 IU/day for 12 weeks in participants with vitamin D deficiency (VDD)
- Interventionn = 103
- Outcome
- Serum 25(OH)D concentration (before to after supplementation)
- Follow-up
- 12 weeks
Main finding
As reported in the abstract
Serum 25(OH)D increased from 19.2 ± 6.2 to 30.9 ± 10.1 ng/mL
Glass's Delta = 1.2; CI 0.8/−1.4
Further findings
Glycemic control · 12 weeks
- Minimal effect on glycemic control
- Glass's Delta = 0.1; CI −0.2/0.4
Factors associated with serum 25(OH)D and HbA1c · after 12 weeks of supplementation
- Higher insulin dose associated with lower serum 25(OH)D
- β = −4.6; CI −8.1/−1.1; p = 0.010
- High BMI associated with lower serum 25(OH)D
- β = −0.3; CI - 0.6/−0.01; p = 0.059
- Sedentary associated with higher HbA1c
- β = 0.20; CI - 0.1/0.7; p = 0.004
Original publication
Effect of vitamin D supplementation on glycemic control in children and adolescents with type 1 diabetes mellitus: Data from a controlled clinical trial. Diabetes Res Clin Pract. Published 2 May 2025. doi:10.
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