Leptin and IGF-1 in Infancy Are Associated With Variants in DHCR7 and CYP2R1 That Relate With Type 1 Diabetes and 25OHD
Authors' conclusion
The vitamin D metabolism genes DHCR7 and CYP2R1 might influence infancy leptin and IGF-1 levels respectively. These findings open the possibility for a developmental role of vitamin D that is mediated by growth-related hormones with implications for the onset of type 1 diabetes autoimmunity.
Study context
- Population
- Infants from the Cambridge Baby Growth Study (newborns from Cambridgeshire, UK, followed in infancy)infants genotyped
- Participants
- 612 infants
- Exposure
- Diabetes risk-increasing alleles of vitamin D metabolism gene SNPs vs other alleles
- Outcome
- Associations of T1D risk-increasing alleles with infant growth and growth-related hormones
Methodological detailsgenetic association analysis, multivariate linear regression
- Genetic association analysis
- Multivariate linear regression
Main finding
As reported in the abstract
Birth weight, CYP2R1 rs10741657 (borderline), β
−.11
P = .02
Birth weight, CYP2R1 rs12794714 (borderline), β
−.09
P = .04
Higher IGF-1 at 24 months, CYP2R1 rs12794714, β
.30
P = .01
Leptin at 3 months, DHCR7 rs12785878 (allele negatively associated with 25(OH)D), β
.23
P = .009
Observational data: associations, not effects.
Further findings
Leptin at 3 months, DHCR7 rs12785878, by sex
- Association pronounced in girls
- P = 0.004
- Boys
- P = 0.7
Original publication
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